Investigating Urinary Pathogens and Their Antibiotic Resistance: A Cross-Sectional Urine Culture Study.
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Authors
Khan, Muzamil
Hussain, Fazeel
Naseem, Muhammad
Clementina, Ruchira
Gul, Nida
Habib, Aysha
Khan, Laiba Ali
Ali, Ayaz
Rahim, Waqas
Khan, Izhar
Issue Date
2024-07-02
Type
Journal Article
Language
en
Keywords
antimicrobial resistance , escherichia coli , proteus mirabilis , urinary tract infection , uropathogens
Alternative Title
Abstract
Introduction: Urinary tract infections (UTIs) are among the most prevalent infectious diseases. Females are more affected than males. The primary culprit is Escherichia coli. Multiple research investigations have documented widespread antimicrobial resistance in uropathogens, sparking global concerns, especially regarding the rise of multidrug resistance (MDR).
Methodology: This cross-sectional study was conducted from December 2023 to March 2024. A non-probability purposive sampling technique was employed to select participants, and informed consent was obtained from them. Data were extracted from the culture and sensitivity reports of these patients. The collected data were meticulously entered into IBM SPSS Statistics for Windows, Version 21 (IBM Corp., Armonk, NY). The findings were then presented using a blend of percentages and numerical figures, offering a clear and concise representation of the data.
Results: Our study of 313 participants showed a higher prevalence of UTIs in females (219, 70%) compared to males (94, 30%). E. coli and Citrobacter were the predominant pathogens, with E. coli and Citrobacter more common in females, while Enterobacter and Staphylococcus were more prevalent in males. Antibiogram analysis revealed sensitivities to specific drugs like nitrofurantoin and meropenem, while resistance was observed against others, including polymyxin B and ampicillin. These findings stress the need for tailored UTI treatment approaches.
Conclusions: In conclusion, our research highlights a concerning trend of escalating antibiotic resistance among Pakistani patients with UTIs. Tobramycin B, ticarcillin-clavulanic acid, ampicillin, and clotrimazole exhibited the highest resistance rates, while imipenem, meropenem, nitrofurantoin, sulfonamides, and tigecycline demonstrated notable sensitivity. These findings emphasize the urgent need for the exploration of alternative treatment options to combat rising resistance levels effectively.
Description
© Copyright 2024 Khan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation
Khan, M.; Hussain, F.; Naseem, M.; Clementina, R.; Gul, N.; Habib, A.; Khan, LA.; Rahim, W. and Khan, I. (2024) 'Investigating Urinary Pathogens and Their Antibiotic Resistance: A Cross-Sectional Urine Culture Study', Cureus, 16(7) e63663. Available at: https://doi.org/10.7759/cureus.63663
Publisher
Springer Nature
License
Copyright © 2024, Khan et al.
Journal
Cureus
Volume
16
Issue
7
PubMed ID
ISSN
2168-8184