Gestational Trophoblastic Neoplasia Rate and Its Related Factors in Women With a Partial Hydatidiform Mole at Tudu Hospital, Vietnam.
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Authors
Vo, Tuan M
Hoang, Tuyet T
Tran, Hoang M
Nyamakope, Kimberley
Issue Date
2024-08-22
Type
Journal Article
Language
en
Keywords
chemoprophylaxis , choriocarcinoma , female patient , gestational trophoblastic neoplasia , partial hydatidiform mole
Alternative Title
Abstract
Background Minimal studies have been carried out on a partial hydatidiform mole (PHM) in Vietnam, so the treatment outcomes for patients with PHM are unknown. This study aimed to determine the occurrence rate of gestational trophoblastic neoplasia (GTN) and its related factors in women with PHM at Tu Du Hospital, Vietnam. Materials and methods This retrospective cohort study included 370 women with PHM diagnosed through a histopathological assessment following termination of pregnancy at Tu Du Hospital from January 2020 to December 2021. Survival analysis was used for GTN cumulative rate estimation and the Cox regression model for determining GTN-related factors. Results After a 1-year follow-up, 21 patients were found to have GTN, exhibiting a rate of 5.7% (95% confidence interval (CI): 3.5 - 8.4). GTN occurred 4.67±2.23 weeks following curettage with peaks at weeks 3-6. No cases of GTN were recorded eight weeks following termination by curettage. After multivariate analysis, the GTN rate was higher in patients with a history of miscarriage/termination (hazard ratio (HR)=2.84; 95% CI: 1.05-7.69). Conclusion The rate of GTN in PHM patients was 5.7%. Patients who had a history of miscarriage or termination were 2.84 times more likely to develop GTN than patients who did not.
Description
Vo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation
Vo, TM.; Hoang, TT.; Tran, HM. and Nyamakope, K. (2024) 'Gestational Trophoblastic Neoplasia Rate and Its Related Factors in Women With a Partial Hydatidiform Mole at Tudu Hospital, Vietnam', Cureus, 16(8) e67495. Available at: https://doi.org/10.7759/cureus.67495
Publisher
Springer Nature
License
Copyright © 2024, Vo et al.
Journal
Cureus
Volume
16
Issue
8
PubMed ID
ISSN
2168-8184