Exhaled volatile organic compounds in the detection of colorectal cancer: a systematic review and meta-analysis.
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Authors
Alsaadi, Daniah
Clements, Nicolle
Gabuniya, Natiya
Francis, Nader
Chand, Manish
Issue Date
2024-05-17
Type
Journal Article
Language
en
Keywords
breath analysis , colorectal cancer , exhaled , volatile organic compounds
Alternative Title
Abstract
There is an apparent need for novel non-invasive colorectal cancer (CRC) screening tests that are more acceptable to patients and can reliably detect CRC or reduce the number of unnecessary colonoscopies performed in cancer-free patients. An emerging number of studies demonstrate the potential value of exhaled volatile organic compounds (VOCs) as a diagnostic and triaging test for CRC. A systematic appraisal and meta-analysis of the published evidence was done to determine whether exhaled VOCs can be used in the detection and screening of CRC. Nine electronic databases were searched from inception of the databases until August 2020. Quantitative and descriptive data of CRC patients and healthy control (HC) participants who underwent VOCs breath analysis was extracted. In addition, where possible, sampling methods, analytical platforms, processors, and specific breath biomarkers found in each study were recorded. Fourteen articles were included in the systematic review with 491 colorectal patients and 754 HC participants (n=1245). Sub-group meta-analysis was conducted on nine of those articles and the pooled sensitivity was estimated to be 0.89 (95 % CI = 0.80-0.99) whereas specificity was 0.83 (95 % CI = 0.74-0.92). Heterogeneity of pooled sensitivity and specificity was estimated as I=11.11 %. Although this study was limited by small sample size and different analytical platforms, the proposed future framework resolves such limitations and standardizes future research. It is reasonable to deduce that VOCs breath analysis is certainly a field of research that can progress to replace traditional methods within the framework of CRC screening and diagnosis.
Description
Copyright (c) 2024 Daniah Alsaadi, Nicolle Clements, Natiya Gabuniya, Nader Francis, Manish Chand
This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0/).
Citation
Alsaadi, D.; Clements, N.; Gabuniya, N.; Francis, N. and Chand, M. (2024) 'Exhaled volatile organic compounds in the detection of colorectal cancer: a systematic review and meta-analysis', EXCLI Journal 23 pp. 795-810. Available at: https://doi.org/10.17179/excli2024-7042
Publisher
EXCLI Journal
License
Copyright © 2024 Alsaadi et al.
Journal
EXCLI journal
Volume
23
Issue
PubMed ID
ISSN
1611-2156