Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria.
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Authors
Odunlami, Gbenga Joshua
Ajibade, Adeola
Omotoso, Bolanle Aderonke
Hassan, Muzamil Olamide
Adefidipe, Adeyemi Abiola
Olanrewaju, Fatai Olatunde
Enitan, Ademola Olusegun
Adetunji, Tajudin Adesegun
Akinyele, Olumide Akinniyi
Okunola, Oluyomi
Issue Date
2024-05-10
Type
Journal Article
Language
en
Keywords
Wessex Classification Subject Headings::Diseases & disorders of systemic, metabolic or environmental origin::Rheumatology
Alternative Title
Abstract
The aims were to study the sociodemographic characteristics of patients presenting to the clinic and to study the clinical and serological pattern of systemic lupus erythematosus (SLE) in a new rheumatology clinic of a predominantly Yoruba population. This was a retrospective, cross-sectional study conducted over 7 years (January 2017 - December 2023). Patients who satisfied the 1997 American College of Rheumatology (ACR) and/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria were enrolled using their medical records. Patients with overlap syndromes and other inflammatory or noninflammatory rheumatic diseases were excluded from the study. Their sociodemographic, clinical, laboratory, and treatment data were retrieved from their medical records and analysed using IBM SPSS version 23.0 software. A total of 65 patients were diagnosed with SLE with a frequency of 15.8%. The mean age ±SD of the patients at presentation was 33.85 years ±11.01 and the female to male ratio was 9.8 : 1. The median (IQR) duration of symptoms at presentation was 7.0 months (3-24). The common clinical presentations included synovitis (86.2%), acute cutaneous rash (53.8%), oral ulcers (52.3%), nonscarring alopecia (50.8%), and serositis (47.7%). Proteinuria was seen in 37.7% of the patients and the predominant renal histopathological feature was Class IV. Antinuclear antibody was 100% positive with 50.94% of the patients having a titre of 1 : 5,120 and above. Anti-double-stranded deoxyribonucleic acid and anti-Smith antibodies each had 50% prevalence. Dyslipidaemia was found in 76.7% of the patients. The study's findings are largely consistent with similar studies done in Africa. Further prospective multi-centred studies are needed to further determine the epidemiological characteristics of the disease in Nigeria with a multi-ethnic population.
Description
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0
Citation
Odunlami, GJ.; Ajibade, A.; Omotoso, BA.; Hassan, MO.; Adefidipe, AA.; Olanrewaju, FO.; Enitan, AO.; Adetunji, TA.; Akinyele, OA.; and Okunola, O. (2024) 'Clinical and laboratory profiles of systemic lupus erythematosus patients in a new rheumatology clinic in southwestern Nigeria', Rheumatologia, 62(2) pp.83-83. Available at: https://doi.org/10.5114/reum/187208
Publisher
Termedia
License
Copyright: © 2024 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie.
Journal
Reumatologia
Volume
62
Issue
2
PubMed ID
ISSN
0034-6233