Efficacy and tolerability of levetiracetam in people with and without intellectual disabilities: A naturalistic case control study.
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Authors
Allard, Jon
Sellers, Adrian
Henley, William
McLean, Brendan
Parrett, Mary
Rajakulendran, Sanjeev
Watkins, Lance
Maguire, Melissa
Ellawela, Shan
Tittensor, Phil
Issue Date
2024-05-16
Type
Journal Article
Language
en
Keywords
Antiseizure medication , Developmental disorder , Intellectual disabilities , Learning disability , Neurodevelopment , Seizures , Wessex Classification Subject Headings::Mental health
Alternative Title
Abstract
People with Intellectual Disabilities (PwID) are twenty times more likely than general population to have epilepsy. Guidance for prescribing antiseizure medication (ASM) to PwID is driven by trials excluding them. Levetiracetam (LEV) is a first-line ASM in the UK. Concerns exist regarding LEV's behavioural and psychological adverse effects, particularly in PwID. There is no high-quality evidence comparing effectiveness and adverse effects in PwID to those without, prescribed LEV. Pooled casenote data for patients prescribed LEV (2000-2020) at 18 UK NHS Trusts were analysed. Demographics, starting and maximum dose, adverse effects, dropouts and seizure frequency between ID (mild vs. moderate-profound (M/P)) and general population for a 12-month period were compared. Descriptive analysis, Mann-Whitney, Fisher's exact and logistic regression methods were employed.
Description
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Citation
Allard J, Sellers A, Henley W, McLean B, Parrett M, Rajakulendran S, Watkins L, Maguire M, Ellawela S, Tittensor P, Bransgrove J, Sen A, Mohanraj R, Bagary M, Ram S, Vernon N, Baldwin S, Gill J, Shankar R. Efficacy and tolerability of levetiracetam in people with and without intellectual disabilities: A naturalistic case control study. Seizure. 2024 Aug;120:25-32.
Publisher
Elsevier
License
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Journal
Seizure
Volume
120
Issue
PubMed ID
ISSN
1532-2688