Nonseizure Response to ECT in Older Adults with Bipolar Depression on Bumetanide
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Authors
Badagala, Aparna
De Souza, Stephen
Issue Date
2024-09-17
Type
Article
Language
en
Keywords
Wessex Classification Subject Headings::Psychology , Wessex Classification Subject Headings::Mental health
Alternative Title
Abstract
Psychiatric presentations in older adults are complicated by chronic comorbidities, polypharmacy, and older age-related psychosocial changes. This case report discusses an unusual treatment response to ECT in a 75-year-old man with chronic bipolar disorder. There was no seizure activity on EEG and upon direct observation in 3 out of 7 ECT sessions. After an in-depth medication review of its impact on ECT, we propose that bumetanide could likely have contributed to the nonseizure response. Bumetanide was proposed as a potential antiepileptic agent, but the evidence for its effect on ECT is sparse. A proportion of older adults receiving ECT are likely to be on this FDA-approved diuretic for cardiovascular comorbidities. This case highlights the need for further studies to test for ECT-modifying of bumetanide
Description
Citation
Badagala, A. and De Souza, S. (2024) 'Nonseizure Response to ECT in Older Adults with Bipolar Depression on Bumetanide', GeroPsych. Available at: https://doi.org/10.1024/1662-9647/a000341
Publisher
Hogrefe AG
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Journal
Volume
Issue
PubMed ID
ISSN
1662-9647