A to F Think MF! A Memory Aid for the Early Recognition of Mycosis Fungoides/Sézary syndrome.
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Authors
Molloy, Kevin
Wachsmuth, Rachel
Murphy, Ruth
Farquharson, Nina
Scarisbrick, Julia
Issue Date
2025-09-15
Type
Journal Article
Language
en
Keywords
Alternative Title
Abstract
Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of rare non-Hodgkin lymphomas that account for approximately 75% of all cutaneous lymphomas. Classic mycosis fungoides (MF), its variants, and Sézary syndrome (SS) are the most common types of CTCL, with an estimated annual incidence of 0.3–0.9/100 000 population and 0.1/1 000 000 population, respectively, in Europe. Patients with early-stage MF (stage IA–IIA) have predominantly skin-limited disease with patches and/or plaques with or without nonlymphomatous lymphadenopathy (typically due to dermatopathic changes or early nodal involvement without effacement of architecture) and no or minimal blood involvement. Early-stage MF is associated with a favourable 10-year overall survival rate. Late-stage MF/SS is characterized by any tumour (IIB), erythroderma, lymph node effacement, blood involvement (meeting criteria for SS) or visceral disease. In contrast to early-stage disease, survival is poor (10-year overall survival 15–53%) for late-stage MF/SS. The risk of progression from early- to late-stage disease has been estimated to be 10–30%.1,2 Across all stages, severe itch is one of the most distressing symptoms for patients, leading not only to impaired quality of life, but also to a significant emotional burden. When compounded by a delayed diagnosis, this psychological toll is further amplified, underscoring the importance of timely recognition.
Description
Citation
Molloy, K. et al. (2025) 'A to F Think MF! A memory aid for early recognition of mycosis fungoides/Sézary syndrome', British Journal of Dermatology. Available at: https://doi.org/10.1093/bjd/ljaf367
Publisher
Oxford University Press
License
Journal
The British journal of dermatology
Volume
Issue
PubMed ID
ISSN
1365-2133