Transcatheter Tricuspid Valve Interventions: a Narrative Review of Current Evidence and Future Directions
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Authors
Gupta, Rahul
Abdul-Rahman, Toufik
Gaur, Aditya
Roy, Poulami
Thaalibi, Hala Ibrahim
Kundu, Mrinmoy
Wireko, Andrew Awuah
Davila, Carlos D.
Issue Date
2025-07-31
Type
Article
Language
en
Keywords
Alternative Title
Abstract
Purpose of Review
The review aims to delineate the developing role of transcatheter tricuspid valve interventions (TTVIs) whilst considering the current state of the evidence, preprocedural workup, developments, and outcomes based on current literature.
Recent Findings
TTVIs have made significant improvements in reducing TR and improving functional status in patients, especially in high-risk surgical cohorts. Innovations in device technology, such as the EVOQUE and LuX valves, have widened the scope of this intervention, offering tailored solutions for a wide range of anatomical and clinical challenges. Comparative analyses have indicated higher procedural success rates and improved patient outcomes compared to traditional surgical interventions.
Summary
TTVIs are redefining the management of tricuspid valve dysfunction by offering an effective and less invasive alternative to surgery. Despite promising short-term outcomes, questions of long-term durability require further research. Further innovation as well as larger clinical trials, will ensure this technique becomes a cornerstone in tricuspid valve management.
Opinion Statement
Transcatheter tricuspid valve interventions (TTVIs) represent a growing milestone in addressing tricuspid valve disorder, especially in high-risk surgery patients. These minimally invasive therapies overcome the disadvantages of traditional surgical/medical treatments by offering new and safer options with lower perioperative morbidity/mortality rates. Already accrued clinical data indicate that these procedures are feasible and safe, facilitating functional improvement and reduction in current tricuspid regurgitation. Nevertheless, several challenges remain. Anatomical and hemodynamic variability and the need to individualize treatment should be contemplated, thus emphasizing the need for pre-procedural planning for optimal outcomes. In addition, complications such as valve migration, leaflet tethering, and conduction disturbances underline the necessity for meticulous procedural multidisciplinary evaluation. Furthermore, long-term durability remains an area requiring further exploration. We recommend integrating TTVIs into a comprehensive structural program. In order to ensure efficacy and define guidelines, future research should continue to focus on randomized trials to validate these findings and to allow broader clinical adoption.
Description
Citation
Gupta, R. et al. (2025) 'Transcatheter Tricuspid Valve Interventions: a Narrative Review of Current Evidence and Future Directions', Current Treatment Options in Cardiovascular Medicine. 27(53). Available At: https://doi.org/10.1007/s11936-025-01104-3
Publisher
Springer Nature
License
Journal
Volume
Issue
PubMed ID
ISSN
1534-3189